Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

Loss of function of TET2 cooperates with constitutively active KIT in murine and human models of mastocytosis.

Systemic Mastocytosis (SM) is a clonal disease characterized by abnormal accumulation of mast cells in multiple organs. Clinical presentations of the disease vary widely from indolent to aggressive forms, and to the exceedingly rare mast cell leukemia. Current treatment of aggressive SM and mast cel...

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Bibliographic Details
Main Authors: Serena De Vita, Rebekka K Schneider, Michael Garcia, Jenna Wood, Mathilde Gavillet, Benjamin L Ebert, Alexander Gerbaulet, Axel Roers, Ross L Levine, Ann Mullally, David A Williams
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096209&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0096209&type=printable

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