VenusMutHub: A systematic evaluation of protein mutation effect predictors on small-scale experimental data

In protein engineering, while computational models are increasingly used to predict mutation effects, their evaluations primarily rely on high-throughput deep mutational scanning (DMS) experiments that use surrogate readouts, which may not adequately capture the complex biochemical properties of int...

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Bibliographic Details
Main Authors: Liang Zhang, Hua Pang, Chenghao Zhang, Song Li, Yang Tan, Fan Jiang, Mingchen Li, Yuanxi Yu, Ziyi Zhou, Banghao Wu, Bingxin Zhou, Hao Liu, Pan Tan, Liang Hong
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Acta Pharmaceutica Sinica B
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Online Access:http://www.sciencedirect.com/science/article/pii/S2211383525001650
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