Reduced synaptic tagging by complement protein C3 is associated with elevated extracellular matrix in the middle-aged cerebellum of mice

BackgroundAging of the brain is associated with cognitive decline and recognized as a major risk factor for the development of neurodegenerative diseases. On a cellular level, brain aging is accompanied by a progressive increase of the basal pro-inflammatory tonus, leading to the activation of phago...

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Bibliographic Details
Main Authors: Henning Peter Düsedau, Carla Cangalaya, Stoyan Stoyanov, Alexander Dityatev, Ildiko Rita Dunay
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Aging Neuroscience
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Online Access:https://www.frontiersin.org/articles/10.3389/fnagi.2025.1616390/full
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