Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies

Insights into KMT2A rearrangements in acute myeloid leukemia: from molecular characteristics to targeted therapies

Abstract Acute myeloid leukemia (AML) with KMT2A rearrangements (KMT2A-r) represents a highly aggressive and prognostically unfavorable subtype of leukemia, often resistant to standard treatments and associated with high relapse rates. KMT2A-r, found in 3–10% of adult AML cases, disrupt epigenetic r...

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Bibliographic Details
Main Authors: Sara Zehtabcheh, Hamed Soleimani Samarkhazan, Marjan Asadi, Mitra Zabihi, Sahar Parkhideh, Mohammad Hossein Mohammadi
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Biomarker Research
Subjects:
Acute myeloid leukemia
KMT2A rearrangement
Menin inhibitors
DOT1L inhibitors
Online Access:https://doi.org/10.1186/s40364-025-00786-y
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https://doi.org/10.1186/s40364-025-00786-y

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