Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism

Resilience of striatal synaptic plasticity over early structural adaptations in premotor parkinsonism

Abstract Parkinson’s disease has a long premotor phase with ongoing dopaminergic degeneration, yet its compensatory mechanisms remain unclear. Using a rat model with A53T α-synuclein overexpression in the substantia nigra, we analyzed striatal synaptic changes at 72 h, 1, 2, and 4 weeks post-inocula...

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Main Authors: Leyre Merino-Galán, Marta Zamarbide, Arantzazu Belloso-Iguerategui, Marta C. Alonso-Moreno, Belén Gago, Alejandro Reinares-Sebastián, Javier Blesa, Dani Dumitriu, Ana Quiroga-Varela, María Cruz Rodríguez-Oroz
Format: Article
Language:English
Published: Nature Portfolio 2025-06-01
Series:npj Parkinson's Disease
Online Access:https://doi.org/10.1038/s41531-025-00994-1
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https://doi.org/10.1038/s41531-025-00994-1

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