Effect of <i>CYP1A2</i>, <i>CYP2D6</i>, and <i>CYP3A4</i> Variation on Antipsychotic Treatment Outcomes

Effect of <i>CYP1A2</i>, <i>CYP2D6</i>, and <i>CYP3A4</i> Variation on Antipsychotic Treatment Outcomes

<b>Background/Objectives:</b> Antipsychotic treatment response varies considerably between individuals, with one potential reason being genetic variation affecting the cytochrome P450 enzymes that metabolise them. <b>Methods</b>: With a diverse sample of 453 participants, we...

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Main Authors: Lauren Varney, Stephen Murtough, Marius Cotic, Rosemary Abidoph, Lian Chan, Noushin Saadullah Khani, Alvin Richards-Belle, Maria Richards-Brown, Daisy Mills, Daniele Panconesi, Yogita Dawda, Parveen Sharma, Chetan Shah, Agostina Secchi, Ramin Nilforooshan, Santosh Mudholkar, Rosie Murdoch, Jazmin Molai, Rebecca Griffiths, Suruthy Senthilkumar, Helen Blake, Steve Lankshear, Jennifer McRoberts, Bethany Pastor, Carmel Thomas, Sabrina Richards, Alison Welfare-Wilson, Sai-Bo Cheung, Rebecca Cox, Anita Chinazam Jibero, Reanne Anad, Rebeka Laczik, Sharif Ghali, Alex J. Berry, Joanna Curwen, Koye Odutoye, Girija Kottalgi, Sally Williams, Solomon Wong, Nithya Anandan, Georgy Pius, Tonye Ajiteru, Victoria Clark, Philip van Driel, Amir Bashir, Samantha Court, Minerva Pawsey, Anna Skowronska, Jessica Woodley, Elvira Bramon
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
pharmacogenetics
<i>CYP1A2</i>
<i>CYP2D6</i>
<i>CYP3A4</i>
antipsychotics
psychosis
Online Access:https://www.mdpi.com/1424-8247/18/6/892
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