A Review of Emerging Neoadjuvant Intravesical Strategies to Enhance Systemic Immune Checkpoint Blockade in Patients With Cisplatin-Ineligible Muscle-Invasive Bladder Cancer Through the Induction of Immunogenic Cell Death and Activation of Tertiary Lymphoid Structure formation

A Review of Emerging Neoadjuvant Intravesical Strategies to Enhance Systemic Immune Checkpoint Blockade in Patients With Cisplatin-Ineligible Muscle-Invasive Bladder Cancer Through the Induction of Immunogenic Cell Death and Activation of Tertiary Lymphoid Structure formation

Patients diagnosed with muscle-invasive bladder cancer (MIBC) frequently exhibit a high incidence of micrometastatic disease. The current standard of care for localized MIBC involves cisplatin-based neoadjuvant chemotherapy followed by radical cystectomy. Novel treatment alternatives in the neoadjuv...

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Bibliographic Details
Main Authors: Hye Won Lee, Hyun Hwan Sung
Format: Article
Language:English
Published: Korean Urological Oncology Society 2025-03-01
Series:Journal of Urologic Oncology
Subjects:
muscle-invasive bladder cancer
immune checkpoint inhibitors
intravesical therapy
tertiary lymphoid structures
immunogenic cell death
Online Access:http://www.e-juo.org/upload/pdf/juo-255000300015.pdf
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http://www.e-juo.org/upload/pdf/juo-255000300015.pdf

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