Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma

Abnormal phosphorylation of human LRH1 at Ser510 predicts poor prognosis and promotes cell viability in lung squamous cell carcinoma

Abstract The nuclear receptor liver receptor homolog 1 (LRH1)/NR5A2 is aberrantly expressed in diverse cancer types, including liver and lung cancers. Since we previously showed that excessive phosphorylation of human LRH1 at S510 (hLRH1pS510-high) is predictable of hepatocellular carcinoma recurren...

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Bibliographic Details
Main Authors: Hayato Mine, Kotaro Sugimoto, Makoto Kobayashi, Hironori Takagi, Naoyuki Okabe, Satoshi Muto, Yasuyuki Kobayashi, Yuko Hashimoto, Hiroyuki Suzuki, Hideki Chiba
Format: Article
Language:English
Published: BMC 2025-04-01
Series:BMC Cancer
Subjects:
Nuclear receptor
NR5A2
Liver receptor homolog 1
Lung cancer
Lung adenocarcinoma
Biomarker
Online Access:https://doi.org/10.1186/s12885-025-14160-6
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https://doi.org/10.1186/s12885-025-14160-6

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