Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach
Environmental microbes are an underexploited resource for the discovery of bioactive compounds. An integrated approach combining reversed-phase high-performance liquid chromatography and high-resolution tandem mass spectrometry with the use of molecular networks was applied to annotate novel chemica...
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| Format: | Article |
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Académie des sciences
2024-02-01
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| Series: | Comptes Rendus. Chimie |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.259/ |
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| author | Nguyen, Dung Levasseur, Marceau Segret, Juliette Sorres, Jonathan Hebra, Téo Touboul, David Eparvier, Véronique |
| author_facet | Nguyen, Dung Levasseur, Marceau Segret, Juliette Sorres, Jonathan Hebra, Téo Touboul, David Eparvier, Véronique |
| author_sort | Nguyen, Dung |
| collection | DOAJ |
| description | Environmental microbes are an underexploited resource for the discovery of bioactive compounds. An integrated approach combining reversed-phase high-performance liquid chromatography and high-resolution tandem mass spectrometry with the use of molecular networks was applied to annotate novel chemical structures with potential antimicrobial activities. This metabolomic approach coupled with biological screening of environmental strains allowed the identification of 22 compounds, including 11 glucosamine derivatives and 10 cyclopeptides, from a bacterial strain of Serratia marcescens. Three new glucosamine derivatives and two stephensiolides were annotated. Two antibacterial stephensiolides, named stephensiolides E and F, were isolated to confirm annotations. |
| format | Article |
| id | doaj-art-77f45d4ee032400d9b307036a25df4dd |
| institution | Kabale University |
| issn | 1878-1543 |
| language | English |
| publishDate | 2024-02-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus. Chimie |
| spelling | doaj-art-77f45d4ee032400d9b307036a25df4dd2025-02-07T13:38:15ZengAcadémie des sciencesComptes Rendus. Chimie1878-15432024-02-0126S2839510.5802/crchim.25910.5802/crchim.259Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approachNguyen, Dung0Levasseur, Marceau1Segret, Juliette2Sorres, Jonathan3Hebra, Téo4Touboul, David5https://orcid.org/0000-0003-2751-774XEparvier, Véronique6https://orcid.org/0000-0002-2954-0866Université Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceLaboratoire de Chimie Moléculaire (LCM), CNRS UMR 9168, École Polytechnique, Institut Polytechnique de Paris, 91128 Palaiseau, France; Université Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceUniversité Paris-Saclay, CNRS, Institut de Chimie Des Substances Naturelles, UPR 2301, 91198 Gif-Sur-Yvette, FranceEnvironmental microbes are an underexploited resource for the discovery of bioactive compounds. An integrated approach combining reversed-phase high-performance liquid chromatography and high-resolution tandem mass spectrometry with the use of molecular networks was applied to annotate novel chemical structures with potential antimicrobial activities. This metabolomic approach coupled with biological screening of environmental strains allowed the identification of 22 compounds, including 11 glucosamine derivatives and 10 cyclopeptides, from a bacterial strain of Serratia marcescens. Three new glucosamine derivatives and two stephensiolides were annotated. Two antibacterial stephensiolides, named stephensiolides E and F, were isolated to confirm annotations.https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.259/<i>Serratia marcescens</i>Environmental microorganismAntimicrobialStephensiolideGlucosamine |
| spellingShingle | Nguyen, Dung Levasseur, Marceau Segret, Juliette Sorres, Jonathan Hebra, Téo Touboul, David Eparvier, Véronique Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach Comptes Rendus. Chimie <i>Serratia marcescens</i> Environmental microorganism Antimicrobial Stephensiolide Glucosamine |
| title | Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach |
| title_full | Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach |
| title_fullStr | Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach |
| title_full_unstemmed | Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach |
| title_short | Identification of defensive antimicrobial compounds from environmental Serratia marcescens SNB-CN88 strain associated with macro-holobiont (termite nest) using a molecular network approach |
| title_sort | identification of defensive antimicrobial compounds from environmental serratia marcescens snb cn88 strain associated with macro holobiont termite nest using a molecular network approach |
| topic | <i>Serratia marcescens</i> Environmental microorganism Antimicrobial Stephensiolide Glucosamine |
| url | https://comptes-rendus.academie-sciences.fr/chimie/articles/10.5802/crchim.259/ |
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