Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians

Multi-trait genetic analysis of asthma and eosinophils uncovers pleiotropic loci in East Asians

Abstract Asthma is a prevalent respiratory condition with over 100 genetic loci identified through genome-wide association studies (GWAS). However, the genetic basis of asthma in East Asians remains underexplored. To address this, we performed a comprehensive analysis of shared genetic mechanisms be...

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Main Authors: Lili Zhi, Qiwen Zheng, Yue Jiang, Lu Yu, Linzehao Li, Yingchao Song, Bichen Peng, Chumeng Zhang, Hengxuan Jiang, Ren Li, Frank Mentch, Joseph Glessner, Peilin Jia, Hua Tang, Hakon Hakonarson, Xiao Chang
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-60405-0
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https://doi.org/10.1038/s41467-025-60405-0

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