Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model

Decoding NY-ESO-1 TCR T cells: transcriptomic insights reveal dual mechanisms of tumor targeting in a melanoma murine xenograft model

The development of T cell receptor-engineered T cells (TCR-T) targeting intracellular antigens is a promising strategy for treating solid tumors; however, the mechanisms underlying their effectiveness remain poorly understood. In this study, we employed advanced techniques to investigate the functio...

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Bibliographic Details
Main Authors: Alaa Alsalloum, Saleh Alrhmoun, Olga Perik-Zavosdkaia, Marina Fisher, Marina Volynets, Julia Lopatnikova, Roman Perik-Zavodskii, Julia Shevchenko, Julia Philippova, Olga Solovieva, Evgenii Zavjalov, Vasily Kurilin, Hiroshi Shiku, Alexander Silkov, Sergey Sennikov
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-11-01
Series:Frontiers in Immunology
Subjects:
NY-ESO-1
cancer-testis antigen
TCR T cells
adoptive transfer
xenograft
SK-Mel-37
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1507218/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1507218/full

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