The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis
IntroductionAdnexal masses are a common health issue in gynecology; the challenge lies in the differential diagnosis of these masses. The International Ovarian Tumor Analysis Simple Rules (IOTA-SR) offers the first scoring system to aid in diagnosis. It is based on a set of five ultrasound imaging f...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1474930/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832594080584957952 |
|---|---|
| author | Awadia Gareeballah Moawia Gameraddin Moawia Gameraddin Sultan Abdulwadoud Alshoabi Amirah Alsaedi Maisa Elzaki Walaa Alsharif Ibrahim Mohamed Daoud Ibrahim Mohamed Daoud Shrooq Aldahery Magbool Alelyani Elrashed AbdElrahim Fahad H. Alhazmi Zuhal Y. Hamd Raga Ahmed Abouraida Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mohamed Adam |
| author_facet | Awadia Gareeballah Moawia Gameraddin Moawia Gameraddin Sultan Abdulwadoud Alshoabi Amirah Alsaedi Maisa Elzaki Walaa Alsharif Ibrahim Mohamed Daoud Ibrahim Mohamed Daoud Shrooq Aldahery Magbool Alelyani Elrashed AbdElrahim Fahad H. Alhazmi Zuhal Y. Hamd Raga Ahmed Abouraida Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mohamed Adam |
| author_sort | Awadia Gareeballah |
| collection | DOAJ |
| description | IntroductionAdnexal masses are a common health issue in gynecology; the challenge lies in the differential diagnosis of these masses. The International Ovarian Tumor Analysis Simple Rules (IOTA-SR) offers the first scoring system to aid in diagnosis. It is based on a set of five ultrasound imaging features indicative of a malignant ovarian tumor and five features indicative of a benign tumor. This review aims to assess the diagnostic performance of IOTA-SR for classifying ovarian tumors as benign or malignant.MethodsA systematic review was conducted on MEDLINE, Embase, Google Scholar, Scopus, and Web of Science. The terminologies “IOTA-SR”, “adnexal, mass”, and “ovarian tumors scoring” were employed. Twenty-seven research articles conducted from 2008 to 2022 were included in the meta-analysis; the publication outcome indicates that performance quality tests were extracted directly or indirectly, including true positive (TP), false positive (FP), true negative (TN), and false negative (FN). The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate the study quality and estimate the risk of bias. After estimating the pooled effect of the sensitivity, specificity, and diagnostic odds ratio (DOR), the summary receiver operating characteristic (SROC) curve was estimated using the bivariate random effects model. Utilizing Cochran’s Q statistics and Higgins’s inconsistency test through the I2 index for pooled analysis, the heterogeneity of studies was quantitatively evaluated. The funnel plot and Egger’s test were utilized to visually and quantitatively evaluate potential publication bias.ResultsAmong 27 studies, including 7,841 adnexal masses, the results of this meta-analysis showed excellent diagnostic performance with a pooled sensitivity of 92% [95% confidence interval (CI), 0.89–0.94] and a pooled specificity of 92% (95% CI, 0.89–0.94). The IOTA-SR was applicable in 85.7% of adnexal masses.ConclusionThe IOTA-SR is highly effective in the presurgical differentiation of malignant versus benign adnexal masses when applied by an expert ultrasonography operator. |
| format | Article |
| id | doaj-art-77d0b503dd384f088b5c3bed5a81fe3d |
| institution | Kabale University |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-77d0b503dd384f088b5c3bed5a81fe3d2025-01-20T05:23:42ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-01-011410.3389/fonc.2024.14749301474930The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysisAwadia Gareeballah0Moawia Gameraddin1Moawia Gameraddin2Sultan Abdulwadoud Alshoabi3Amirah Alsaedi4Maisa Elzaki5Walaa Alsharif6Ibrahim Mohamed Daoud7Ibrahim Mohamed Daoud8Shrooq Aldahery9Magbool Alelyani10Elrashed AbdElrahim11Fahad H. Alhazmi12Zuhal Y. Hamd13Raga Ahmed Abouraida14Mayeen Uddin Khandaker15Mayeen Uddin Khandaker16Mayeen Uddin Khandaker17Mohamed Adam18Department of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaFaculty of Radiological Sciences and Medical Imaging, Alzaiem Alazhari University, Khartoum, SudanDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Obstetrics and Gynecology, Faculty of Medicine, Alneelain University, Khartoum, SudanDepartment of Obstetrics and Gynecology, Batterjee Medical College (BMC), Abha, Saudi ArabiaDepartment of Applied Radiologic Technology, College of Applied Medical Sciences, University of Jeddah, Jeddah, Saudi ArabiaDepartment of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi ArabiaRadiological Sciences Department, College of Applied Medical Sciences, Taif University, Taif, Saudi ArabiaDepartment of Diagnostic Radiology, College of Applied Medical Sciences, Taibah University, Al-Madinah Al-Munawwarah, Saudi ArabiaDepartment of Radiological Sciences, College of Health and Rehabilitation Sciences, Princess Nourah bint Abdulrahman University, Riyadh, Saudi ArabiaDepartment of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi ArabiaCentre for Applied Physics and Radiation Technologies, School of Engineering and Technology, Sunway University, Bandar Sunway, Malaysia0Faculty of Graduate Studies, Daffodil International University, Savar, Bangladesh1Department of Physics, College of Science, Korea University, Seoul, Republic of KoreaDepartment of Radiological Sciences, College of Applied Medical Sciences, King Khalid University, Abha, Saudi ArabiaIntroductionAdnexal masses are a common health issue in gynecology; the challenge lies in the differential diagnosis of these masses. The International Ovarian Tumor Analysis Simple Rules (IOTA-SR) offers the first scoring system to aid in diagnosis. It is based on a set of five ultrasound imaging features indicative of a malignant ovarian tumor and five features indicative of a benign tumor. This review aims to assess the diagnostic performance of IOTA-SR for classifying ovarian tumors as benign or malignant.MethodsA systematic review was conducted on MEDLINE, Embase, Google Scholar, Scopus, and Web of Science. The terminologies “IOTA-SR”, “adnexal, mass”, and “ovarian tumors scoring” were employed. Twenty-seven research articles conducted from 2008 to 2022 were included in the meta-analysis; the publication outcome indicates that performance quality tests were extracted directly or indirectly, including true positive (TP), false positive (FP), true negative (TN), and false negative (FN). The Quality Assessment of Diagnostic Accuracy Studies 2 (QUADAS-2) was used to evaluate the study quality and estimate the risk of bias. After estimating the pooled effect of the sensitivity, specificity, and diagnostic odds ratio (DOR), the summary receiver operating characteristic (SROC) curve was estimated using the bivariate random effects model. Utilizing Cochran’s Q statistics and Higgins’s inconsistency test through the I2 index for pooled analysis, the heterogeneity of studies was quantitatively evaluated. The funnel plot and Egger’s test were utilized to visually and quantitatively evaluate potential publication bias.ResultsAmong 27 studies, including 7,841 adnexal masses, the results of this meta-analysis showed excellent diagnostic performance with a pooled sensitivity of 92% [95% confidence interval (CI), 0.89–0.94] and a pooled specificity of 92% (95% CI, 0.89–0.94). The IOTA-SR was applicable in 85.7% of adnexal masses.ConclusionThe IOTA-SR is highly effective in the presurgical differentiation of malignant versus benign adnexal masses when applied by an expert ultrasonography operator.https://www.frontiersin.org/articles/10.3389/fonc.2024.1474930/fulladnexal massultrasonographyInternational Ovarian Tumor Analysis Simple RulesIOTA-SRbenign tumormalignant tumor |
| spellingShingle | Awadia Gareeballah Moawia Gameraddin Moawia Gameraddin Sultan Abdulwadoud Alshoabi Amirah Alsaedi Maisa Elzaki Walaa Alsharif Ibrahim Mohamed Daoud Ibrahim Mohamed Daoud Shrooq Aldahery Magbool Alelyani Elrashed AbdElrahim Fahad H. Alhazmi Zuhal Y. Hamd Raga Ahmed Abouraida Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mayeen Uddin Khandaker Mohamed Adam The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis Frontiers in Oncology adnexal mass ultrasonography International Ovarian Tumor Analysis Simple Rules IOTA-SR benign tumor malignant tumor |
| title | The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis |
| title_full | The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis |
| title_fullStr | The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis |
| title_full_unstemmed | The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis |
| title_short | The diagnostic performance of International Ovarian Tumor Analysis: Simple Rules for diagnosing ovarian tumors—a systematic review and meta-analysis |
| title_sort | diagnostic performance of international ovarian tumor analysis simple rules for diagnosing ovarian tumors a systematic review and meta analysis |
| topic | adnexal mass ultrasonography International Ovarian Tumor Analysis Simple Rules IOTA-SR benign tumor malignant tumor |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1474930/full |
| work_keys_str_mv | AT awadiagareeballah thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT moawiagameraddin thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT moawiagameraddin thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT sultanabdulwadoudalshoabi thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT amirahalsaedi thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT maisaelzaki thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT walaaalsharif thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ibrahimmohameddaoud thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ibrahimmohameddaoud thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT shrooqaldahery thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT magboolalelyani thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT elrashedabdelrahim thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT fahadhalhazmi thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT zuhalyhamd thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ragaahmedabouraida thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mohamedadam thediagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT awadiagareeballah diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT moawiagameraddin diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT moawiagameraddin diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT sultanabdulwadoudalshoabi diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT amirahalsaedi diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT maisaelzaki diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT walaaalsharif diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ibrahimmohameddaoud diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ibrahimmohameddaoud diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT shrooqaldahery diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT magboolalelyani diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT elrashedabdelrahim diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT fahadhalhazmi diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT zuhalyhamd diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT ragaahmedabouraida diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mayeenuddinkhandaker diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis AT mohamedadam diagnosticperformanceofinternationalovariantumoranalysissimplerulesfordiagnosingovariantumorsasystematicreviewandmetaanalysis |