Application of Doehlert design combined with chemometrics tools: Example of the optimization of the elution of neurotransmitters and metabolites by HPLC

Experimental designs are essential mathematical tools in fields like agronomy, chemistry, and analytical chemistry for optimizing processes and minimizing variations. Doehlert designs, in particular, are valued for their efficiency in exploring experimental space with minimal experiments, providing...

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Bibliographic Details
Main Authors: Camille Rosier, Bruno P. Guiard, Guillaume Gotti
Format: Article
Language:English
Published: Elsevier 2025-02-01
Series:Heliyon
Subjects:
Online Access:http://www.sciencedirect.com/science/article/pii/S2405844025010710
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