Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles

Linoleic acid metabolite 13-Hydroxyoctadecadienoic acid as a biphasic ferroptosis modulator in granulosa cells: multi-omics analysis of ovine atretic follicles

Introduction13-Hydroxyoctadecadienoic acid (13(S)-HODE) is a bioactive lipid derived from linoleic acid, it plays prominent roles in cellular processes such as lipid metabolism, oxidative stress, and apoptosis. Follicular atresia is a complex physiological process involving multiple forms of cell de...

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Main Authors: Yukun Song, Erhan Hai, Lixia He, Ning Zhang, Nan Zhang, Junlan Wang, Yupeng Sun, Dengke Zeng, Jiaxin Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
ovine atretic follicle
ferroptosis
13-hydroxyoctadecadienoic acid
lipid metabolism
transcriptome and metabolome
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1610621/full
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https://www.frontiersin.org/articles/10.3389/fcell.2025.1610621/full

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