Generation of hypoimmunogenic universal iPS cells through HLA-type gene knockout

Generation of hypoimmunogenic universal iPS cells through HLA-type gene knockout

Abstract Hypoimmunogenic universal induced pluripotent stemn (iPS) cells were generated through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B and HLA-DR alpha (DRA), using the CRISPR–Cas9 system. This approach aimed to minimize immune recognition and enhance...

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Main Authors: Juryun Kim, Yoojun Nam, Doyeong Jeon, Yujin Choi, SeonJu Choi, Chang Pyo Hong, Siyoung Kim, Hyerin Jung, Narae Park, Yeowon Sohn, Yeri Alice Rim, Ji Hyeon Ju
Format: Article
Language:English
Published: Nature Publishing Group 2025-03-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-025-01422-3
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https://doi.org/10.1038/s12276-025-01422-3

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