Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo

Impact of thymoquinone on the Nrf2/HO-1 and MAPK/NF-κB axis in mitigating 5-fluorouracil-induced acute kidney injury in vivo

BackgroundChemotherapy-induced organ toxicity is one of the most common toxic effects of 5-fluorouracil (5-FU) in cancer patients. Therefore, new strategies are needed to prevent chemotherapy-induced kidney toxicity. Thymoquinone (TQ), a constituent of the plant Nigella sativa from the family Renunc...

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Bibliographic Details
Main Author: Summya Rashid
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Oncology
Subjects:
thymoquinone
p38MAPK
NF-kB
inflammation
oxidative stress
redox signaling
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1572095/full
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