Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis

Sphk1/S1P pathway promotes blood-brain barrier breakdown after intracerebral hemorrhage through inducing Nlrp3-mediated endothelial cell pyroptosis

Abstract Intracerebral hemorrhage (ICH) is a severe stroke subtype with high mortality and limited therapeutic options. The blood-brain barrier (BBB) breakdown post-ICH exacerbates secondary brain injury, highlighting the need for targeted therapies to preserve the BBB integrity. We aim to investiga...

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Main Authors: Mengzhao Feng, Yuan An, Qi Qin, Iat-Hang Fong, Kaiyuan Zhang, Fang Wang, Dengpan Song, Mengyuan Li, Min Yu, Chi-Tai Yeh, Junlei Chang, Fuyou Guo
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-024-07310-4
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https://doi.org/10.1038/s41419-024-07310-4

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