Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysisResearch in context

Efficacy and tolerability of pharmacological interventions for schizophrenia non-responsive to prior treatment: a systematic review and network meta-analysisResearch in context

Summary: Background: Treatment-resistant schizophrenia (TRS) poses significant challenges for both clinicians and patients. This systematic review and network meta-analysis (NMA) aimed to compare the efficacy and tolerability of all available pharmacotherapy options. Methods: We systematically sear...

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Main Authors: Myrto Samara, Andreas S. Lappas, Elisavet Pinioti, Eleni Glarou, Iwo Fober, Christos Christogiannis, Spyridon Siafis, Nikos Christodoulou, Bartosz Helfer, Dimitris Mavridis, Stefan Leucht
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:EClinicalMedicine
Subjects:
Resistance
Clozapine
Combination
Augmentation
Antipsychotics
Polypharmacy
Online Access:http://www.sciencedirect.com/science/article/pii/S2589537025002238
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