Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion

Interleukin‐11 promotes lung adenocarcinoma tumourigenesis and immune evasion

Abstract Rationale Interleukin‐11 (IL‐11) has emerged as a significant player in tumourigenesis, with implications across various cancer types. However, its specific role in driving tumour progression in lung adenocarcinoma (LUAD) remains elusive. IL‐11's multifaceted impact on both tumour cell...

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Main Authors: Cristina Cirauqui, Laura Ojeda, Itziar Otano, Irene Pazos, Alba Santos, Eva M. Garrido‐Martín, Patricia Yagüe, Javier Ramos‐Paradas, Sonia Molina‐Pinelo, Giovanna Roncador, José Luis Solórzano, M. Teresa Muñoz, Patricia Cozar, Patricia Plaza, Rocío Suárez, Marta Jiménez, Roberto Moreno, Arantxa Rosado, Pablo Gámez, Ricardo García‐Luján, Jon Zugazagoitia, E. Alejandro Sweet‐Cordero, Mariano Barbacid, Amancio Carnero, Irene Ferrer, Luis Paz‐Ares
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:Clinical and Translational Medicine
Subjects:
lung adenocarcinoma
IL‐11/IL‐11RA axis
tobacco smoke
immunosuppressive tumour microenvironment
therapeutic target
Online Access:https://doi.org/10.1002/ctm2.70374
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https://doi.org/10.1002/ctm2.70374

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