Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma

Missing the mark(ers): circulating endothelial cells and endothelial-derived extracellular vesicles are elevated in sickle cell disease plasma

Sickle cell disease (SCD) is a devastating hemolytic disease, marked by recurring bouts of painful vaso-occlusion, leading to tissue damage from ischemia/reperfusion pathophysiology. Central to this process are oxidative stress, endothelial cell activation, inflammation, and vascular dysfunction. Th...

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Bibliographic Details
Main Authors: Joan D. Beckman, Ping Zhang, Julia Nguyen, Robert P. Hebbel, Gregory M. Vercellotti, John D. Belcher
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-12-01
Series:Frontiers in Immunology
Subjects:
extracellular vesicles (EVs)
endothelium
sickle cell anemia
circulating endothelial cells (CEC)
soluble adhesion molecules
sickle cell pain crisis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493904/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2024.1493904/full

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