DHX9-mediated epigenetic silencing of BECN1 contributes to impaired autophagy and tumor progression in breast cancer via recruitment of HDAC5

Abstract Autophagy is closely linked to tumorigenesis, progression and metastasis. DHX9 is a member of the DExD/H-box helicase family and plays important roles in transcription, translation, RNA editing and non-coding RNA synthesis. Mounting evidence demonstrates that aberrant expression of DHX9 is...

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Bibliographic Details
Main Authors: Ziyang Li, Fang Liu, Fengbei Li, Guopeng Zeng, Xin Wen, Jianan Ding, Jueyu Zhou
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07847-y
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