PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

PI 3‐kinase delta enhances axonal PIP3 to support axon regeneration in the adult CNS

Abstract Peripheral nervous system (PNS) neurons support axon regeneration into adulthood, whereas central nervous system (CNS) neurons lose regenerative ability after development. To better understand this decline whilst aiming to improve regeneration, we focused on phosphoinositide 3‐kinase (PI3K)...

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Main Authors: Bart Nieuwenhuis, Amanda C Barber, Rachel S Evans, Craig S Pearson, Joachim Fuchs, Amy R MacQueen, Susan van Erp, Barbara Haenzi, Lianne A Hulshof, Andrew Osborne, Raquel Conceicao, Tasneem Z Khatib, Sarita S Deshpande, Joshua Cave, Charles Ffrench‐Constant, Patrice D Smith, Klaus Okkenhaug, Britta J Eickholt, Keith R Martin, James W Fawcett, Richard Eva
Format: Article
Language:English
Published: Springer Nature 2020-06-01
Series:EMBO Molecular Medicine
Subjects:
axon transport
CNS axon regeneration
optic nerve
p110 delta
phosphoinositide 3‐kinase
Online Access:https://doi.org/10.15252/emmm.201911674
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https://doi.org/10.15252/emmm.201911674

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