Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression

Japanese encephalitis virus-induced DNA methylation contributes to blood-brain barrier permeability by modulating tight junction protein expression

Abstract Japanese encephalitis virus (JEV) is a neurotropic and neuroinvasive flavivirus causing viral encephalitis, which seriously threatens the development of animal husbandry and human health. DNA methylation is a major epigenetic modification involved in viral pathogenesis, yet how DNA methylat...

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Bibliographic Details
Main Authors: Xiao Xiang, Du Yu, Zhuangzhuang Li, Jelke J. Fros, Jianchao Wei, Ke Liu, Zongjie Li, Donghua Shao, Beibei Li, Jeroen Kortekaas, Monique M. van Oers, Zhiyong Ma, Gorben P. Pijlman, Yafeng Qiu
Format: Article
Language:English
Published: BMC 2024-10-01
Series:Journal of Neuroinflammation
Subjects:
Japanese encephalitis virus
DNA methylation
WGBS
Blood-brain barrier
Afdn
Online Access:https://doi.org/10.1186/s12974-024-03266-6
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https://doi.org/10.1186/s12974-024-03266-6

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