A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors

A whole‐genome scan for Artemisinin cytotoxicity reveals a novel therapy for human brain tumors

Abstract The natural compound Artemisinin is the most widely used antimalarial drug worldwide. Based on its cytotoxicity, it is also used for anticancer therapy. Artemisinin and its derivates are endoperoxides that damage proteins in eukaryotic cells; their definite mechanism of action and host cell...

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Main Authors: Jasmin Taubenschmid‐Stowers, Michael Orthofer, Anna Laemmerer, Christian Krauditsch, Marianna Rózsová, Christian Studer, Daniela Lötsch, Johannes Gojo, Lisa Gabler, Matheus Dyczynski, Thomas Efferth, Astrid Hagelkruys, Georg Widhalm, Andreas Peyrl, Sabine Spiegl‐Kreinecker, Dominic Hoepfner, Shan Bian, Walter Berger, Juergen A Knoblich, Ulrich Elling, Moritz Horn, Josef M Penninger
Format: Article
Language:English
Published: Springer Nature 2023-02-01
Series:EMBO Molecular Medicine
Subjects:
5‐ALA
Artemisinin
genome wide screen
glioblastoma therapy
porphyrin biogenesis
Online Access:https://doi.org/10.15252/emmm.202216959
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https://doi.org/10.15252/emmm.202216959

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