Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas

Optimized culturing yields high success rates and preserves molecular heterogeneity, enabling personalized screening for high-grade gliomas

Abstract To discover new treatment options for high-grade glioma (HGG), robust in vitro models are essential, but reliably establishing patient-derived cell cultures remains challenging. We established glioma stem-like cell (GSC) cultures from 114 consecutive HGG specimens via traditional surgical r...

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Main Authors: Cassandra Posthoorn-Verheul, Federica Fabro, Ioannis Ntafoulis, Chelsea den Hollander, Iris S. C. Verploegh, Rutger Balvers, Trisha V. Kers, Jessica Hoogeveen, Judith van der Burg, Bert Eussen, Annelies de Klein, Kate J. Feller, Miao-Ping Chien, Clemens M. F. Dirven, Sieger Leenstra, Martine L. M. Lamfers
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:npj Precision Oncology
Online Access:https://doi.org/10.1038/s41698-025-00946-1
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https://doi.org/10.1038/s41698-025-00946-1

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