PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT

PD-1 inhibition disrupts collagen homeostasis and aggravates cardiac dysfunction through endothelial-fibroblast crosstalk and EndMT

IntroductionCardiac immune-related adverse events (irAEs) from PD-1-targeting immune check-point inhibitors (ICIs) are an increasing concern due to their high mortality rate. Collagen plays a crucial role in maintaining cardiac structure, elasticity, and signal transduction; however, the effects and...

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Bibliographic Details
Main Authors: Zejin Zhang, Zhenzhen Yan, Tao Yuan, Xiaona Zhao, Minghui Wang, Guoqing Liu, Lijun Gan, Wei Qin
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-03-01
Series:Frontiers in Pharmacology
Subjects:
cardio-oncology
cardiotoxicity
PD-1 inhibitor
collagen distribution
EndMT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1549487/full
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https://www.frontiersin.org/articles/10.3389/fphar.2025.1549487/full

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