Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Predicting Disease Onset from Mutation Status Using Proband and Relative Data with Applications to Huntington's Disease

Huntington's disease (HD) is a progressive neurodegenerative disorder caused by an expansion of CAG repeats in the IT15 gene. The age-at-onset (AAO) of HD is inversely related to the CAG repeat length and the minimum length thought to cause HD is 36. Accurate estimation of the AAO distribution...

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Bibliographic Details
Main Authors: Tianle Chen, Yuanjia Wang, Yanyuan Ma, Karen Marder, Douglas R. Langbehn
Format: Article
Language:English
Published: Wiley 2012-01-01
Series:Journal of Probability and Statistics
Online Access:http://dx.doi.org/10.1155/2012/375935
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