Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control

Senescence-associated lineage-aberrant plasticity evokes T-cell-mediated tumor control

Abstract Cellular senescence is a stress-inducible state switch relevant in aging, tumorigenesis and cancer therapy. Beyond a lasting arrest, senescent cells are characterized by profound chromatin remodeling and transcriptional reprogramming. We show here myeloid-skewed aberrant lineage plasticity...

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Main Authors: Dimitri Belenki, Paulina Richter-Pechanska, Zhiting Shao, Animesh Bhattacharya, Andrea Lau, José Américo Nabuco Leva Ferreira de Freitas, Gregor Kandler, Timon P. Hick, Xiurong Cai, Eva Scharnagl, Aitomi Bittner, Martin Schönlein, Julia Kase, Katharina Pardon, Bernadette Brzezicha, Nina Thiessen, Oliver Bischof, Jan R. Dörr, Maurice Reimann, Maja Milanovic, Jing Du, Yong Yu, Björn Chapuy, Soyoung Lee, Ulf Leser, Claus Scheidereit, Jana Wolf, Dorothy N. Y. Fan, Clemens A. Schmitt
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57429-x
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https://doi.org/10.1038/s41467-025-57429-x

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