Targeting transcription factors through an IMiD independent zinc finger domain

Targeting transcription factors through an IMiD independent zinc finger domain

Abstract Immunomodulatory imide drugs (IMiDs) degrade specific C2H2 zinc finger degrons in transcription factors, making them effective against certain cancers. SALL4, a cancer driver, contains seven C2H2 zinc fingers in three clusters, including an IMiD degron in zinc finger cluster one (ZFC1). Sur...

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Main Authors: Bee Hui Liu, Miao Liu, Sridhar Radhakrishnan, Meng-Yuan Dai, Chaitanya Kumar Jaladanki, Chong Gao, Jing Ping Tang, Kalpana Kumari, Mei Lin Go, Kim Anh L Vu, Junsu Kwon, Hyuk-Soo Seo, Kijun Song, Xi Tian, Li Feng, Justin L Tan, Arek V Melkonian, Zhaoji Liu, Gerburg Wulf, Haribabu Arthanari, Jun Qi, Sirano Dhe-Paganon, John G Clohessy, Yeu Khai Choong, J Sivaraman, Hao Fan, Daniel G Tenen, Li Chai
Format: Article
Language:English
Published: Springer Nature 2025-05-01
Series:EMBO Molecular Medicine
Subjects:
SALL4
Degrader
IMiD
C2H2
Zinc Finger Cluster Four (ZFC4)
Online Access:https://doi.org/10.1038/s44321-025-00241-3
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https://doi.org/10.1038/s44321-025-00241-3

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