Co-stimulation of CD28/CD40 signaling molecule potentiates CAR-T cell efficacy and stemness

Co-stimulation of CD28/CD40 signaling molecule potentiates CAR-T cell efficacy and stemness

CD19 chimeric antigen receptor T (CD19CAR-T) cells have achieved promising outcomes in relapsed/refractory B cell malignancies. However, recurrences occur due to the loss of CAR-T cell persistence. We developed dual T/B cell co-stimulatory molecules (CD28 and CD40) in CAR-T cells to enhance intense...

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Main Authors: Wannakorn Khopanlert, Pongsakorn Choochuen, Kajornkiat Maneechai, Nawaphat Jangphattananont, Socheatraksmey Ung, Shingo Okuno, Peter Steinberger, Judith Leitner, Surasak Sangkhathat, Pongtep Viboonjuntra, Seitaro Terakura, Jakrawadee Julamanee
Format: Article
Language:English
Published: Elsevier 2024-09-01
Series:Molecular Therapy: Oncology
Subjects:
MT: Regular Issue
CD28/CD40
co-stimulatory domain
CD19
CD37
CAR-T cell
Online Access:http://www.sciencedirect.com/science/article/pii/S2950329924000791
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