The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis

The TLR-M-CSF axis is implicated in increased bone turnover and curve progression in adolescent idiopathic scoliosis

Abstract Background Facet joint osteoarthritis (OA) is prevalent in patients with adolescent idiopathic scoliosis (AIS). The most pronounced OA presents above and below the curve's apex where the intervertebral rotation is the greatest. This indicates that facet joint OA is implicated and poten...

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Bibliographic Details
Main Authors: Kai Sheng, Daniel G. Bisson, Neil Saran, Jake Bourdages, Christopher Coluni, Kirby Upshaw, Kerstin Tiedemann, Svetlana V. Komarova, Jean A. Ouellet, Lisbet Haglund
Format: Article
Language:English
Published: BMC 2025-03-01
Series:Arthritis Research & Therapy
Subjects:
Scoliosis
Facet joints
Osteoarthritis
Subchondral bone
Osteoclast
Crosstalk
Online Access:https://doi.org/10.1186/s13075-025-03535-6
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https://doi.org/10.1186/s13075-025-03535-6

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