High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer

High expression of CXCL13 predicts a favorable response to immunotherapy by upregulating CXCR5+CD8+ T-cell infiltration in gastric cancer

IntroductionIdentifying predictive biomarkers for immune checkpoint inhibitor (ICI) treatment is critical for gastric cancer (GC) prognosis. C-X-C motif chemokine ligand 13(CXCL13) plays an important role in immune regulation by binding exclusively to its receptor CXCR5. However, its role, underlyin...

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Bibliographic Details
Main Authors: Shuning Xu, Danyang Li, Tao Ning, Yao Lu, Yansha Sun, Hua Bai, Lei Qiao, Ting Deng, Ying Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
gastric cancer
immunotherapy
prognosis markers
CXCL13
CXCR5
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551259/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1551259/full

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