A refined, minimally invasive, reproducible ovine ischaemia–reperfusion–infarction model using implantable defibrillators: Methodology and validation

Abstract Ischaemic heart disease remains a leading cause of premature mortality and morbidity. Understanding the associated pathophysiological mechanisms of cardiac dysfunction arising from ischaemic heart disease and the identification of sites for new therapeutic interventions requires a preclinic...

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Bibliographic Details
Main Authors: Charlene Pius, Barbara Niort, Emma J. Radcliffe, Andrew W. Trafford
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Experimental Physiology
Subjects:
Online Access:https://doi.org/10.1113/EP091760
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