Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

Downregulation of semaphorin 4A in keratinocytes reflects the features of non-lesional psoriasis

Psoriasis is a multifactorial disorder mediated by IL-17-producing T cells, involving immune cells and skin-constituting cells. Semaphorin 4A (Sema4A), an immune semaphorin, is known to take part in T helper type 1/17 differentiation and activation. However, Sema4A is also crucial for maintaining pe...

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Bibliographic Details
Main Authors: Miki Kume, Hanako Koguchi-Yoshioka, Shuichi Nakai, Yutaka Matsumura, Atsushi Tanemura, Kazunori Yokoi, Shoichi Matsuda, Yuumi Nakamura, Naoya Otani, Mifue Taminato, Koichi Tomita, Tateki Kubo, Mari Wataya-Kaneda, Atsushi Kumanogoh, Manabu Fujimoto, Rei Watanabe
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2024-12-01
Series:eLife
Subjects:
psoriasis
Sema4A
epidermis
keratinocytes
T cells
resident memory T cells
Online Access:https://elifesciences.org/articles/97654
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https://elifesciences.org/articles/97654

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