Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice

Comparative lipidomic and metabolomic profiling of mdx and severe mdx-apolipoprotein e-null mice

Abstract Despite its notoriously mild phenotype, the dystrophin-deficient mdx mouse is the most common model of Duchenne muscular dystrophy (DMD). By mimicking a human DMD-associated metabolic comorbidity, hyperlipidemia, in mdx mice by inactivating the apolipoprotein E gene (mdx-ApoE) we previously...

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Bibliographic Details
Main Authors: Ram B. Khattri, Abhinandan Batra, Zoe White, David Hammers, Terence E. Ryan, Elisabeth R. Barton, Pascal Bernatchez, Glenn A. Walter
Format: Article
Language:English
Published: BMC 2024-12-01
Series:Skeletal Muscle
Subjects:
Duchenne
Fibrofatty infiltration
Metabolism
Muscle
Liver
NMR
Online Access:https://doi.org/10.1186/s13395-024-00368-w
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https://doi.org/10.1186/s13395-024-00368-w

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