A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics.

A randomized pilot study of L-arginine infusion in severe falciparum malaria: preliminary safety, efficacy and pharmacokinetics.

<h4>Background</h4>Decreased nitric oxide (NO) and hypoargininemia are associated with severe falciparum malaria and may contribute to severe disease. Intravenous L-arginine increases endothelial NO in moderately-severe malaria (MSM) without adverse effects. The safety, efficacy and phar...

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Main Authors: Tsin W Yeo, Daniel A Lampah, Indri Rooslamiati, Retno Gitawati, Emiliana Tjitra, Enny Kenangalem, Ric N Price, Stephen B Duffull, Nicholas M Anstey
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0069587
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https://doi.org/10.1371/journal.pone.0069587

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