Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila

Microbiome-emitted scents activate olfactory neuron-independent airway-gut-brain axis to promote host growth in Drosophila

Abstract While it is now accepted that the microbiome has strong impacts on animal growth promotion, the exact mechanism has remained elusive. Here we show that microbiome-emitted scents contain volatile somatotrophic factors (VSFs), which promote host growth in an olfaction-independent manner in Dr...

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Main Authors: Jin-Woo Lee, Kyung-Ah Lee, In-Hwan Jang, Kibum Nam, Sung-Hee Kim, Minsoo Kyung, Kyu-Chan Cho, Ji-hoon Lee, Hyejin You, Eun-Kyoung Kim, Young Hoon Koh, Hansol Lee, Junsun Park, Soo-Yeon Hwang, Youn Wook Chung, Choong-Min Ryu, Youngjoo Kwon, Soung-Hun Roh, Ji-Hwan Ryu, Won-Jae Lee
Format: Article
Language:English
Published: Nature Portfolio 2025-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-57484-4
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https://doi.org/10.1038/s41467-025-57484-4

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