Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

Potent activity of the HIV-1 maturation inhibitor bevirimat in SCID-hu Thy/Liv mice.

<h4>Background</h4>The HIV-1 maturation inhibitor, 3-O-(3',3'-dimethylsuccinyl) betulinic acid (bevirimat, PA-457) is a promising drug candidate with 10 nM in vitro antiviral activity against multiple wild-type (WT) and drug-resistant HIV-1 isolates. Bevirimat has a novel mecha...

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Main Authors: Cheryl A Stoddart, Pheroze Joshi, Barbara Sloan, Jennifer C Bare, Philip C Smith, Graham P Allaway, Carl T Wild, David E Martin
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-11-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001251&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0001251&type=printable

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