Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

Co‐recruitment analysis of the CBL and CBLB signalosomes in primary T cells identifies CD5 as a key regulator of TCR‐induced ubiquitylation

Abstract T‐cell receptor (TCR) signaling is essential for the function of T cells and negatively regulated by the E3 ubiquitin–protein ligases CBL and CBLB. Here, we combined mouse genetics and affinity purification coupled to quantitative mass spectrometry to monitor the dynamics of the CBL and CBL...

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Bibliographic Details
Main Authors: Guillaume Voisinne, Antonio García‐Blesa, Karima Chaoui, Frédéric Fiore, Elise Bergot, Laura Girard, Marie Malissen, Odile Burlet‐Schiltz, Anne Gonzalez de Peredo, Bernard Malissen, Romain Roncagalli
Format: Article
Language:English
Published: Springer Nature 2016-07-01
Series:Molecular Systems Biology
Subjects:
CBL
CBLB
CD5
ubiquitylation
Online Access:https://doi.org/10.15252/msb.20166837
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https://doi.org/10.15252/msb.20166837

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