Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease

Identification of Long Noncoding RNA Candidate Disease Genes Associated With Clinically Reported Copy Number Variants in Congenital Heart Disease

Background Copy number variants (CNVs) contribute to 3% to 10% of isolated congenital heart disease (CHD) cases, yet their pathogenic roles remain unclear. Diagnostic efforts have focused on protein‐coding genes, largely overlooking long noncoding RNAs (lncRNAs), which play key roles in development...

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Bibliographic Details
Main Authors: Jacqueline S. Penaloza, Blythe Moreland, Jeffrey B. Gaither, Benjamin J. Landis, Stephanie M. Ware, Kim L. McBride, Peter White
Format: Article
Language:English
Published: Wiley 2025-03-01
Series:Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Subjects:
congenital heart disease
copy number variants
genomic regulation in cardiovascular development
long noncoding RNAs
weighted gene coexpression network analysis
Online Access:https://www.ahajournals.org/doi/10.1161/JAHA.124.039177
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https://www.ahajournals.org/doi/10.1161/JAHA.124.039177

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