Revealing the mechanisms of warfarin-induced vascular calcification through metabolomics and network toxicology

Warfarin is widely used in clinical anticoagulation therapy, but the exact mechanism by which it induces vascular calcification (VC) remains unclear. This study aimed to explore the mechanisms of warfarin-induced VC using metabolomics and network toxicology approaches. Initially, normal rats were or...

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Bibliographic Details
Main Authors: Zhijiao Zhang, Pengyan Jia, Chunqi Feng, Juan Xu, Jingmin Zhang, Niuniu Bai, Weihong Chen, Weiqi Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
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Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1554987/full
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