Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of <i>Trypanosoma brucei rhodesiense</i>

Synthesis and Combination Studies of Novel Dipeptide Nitriles with Curcumin for a Potent Synergistic Action Against Rhodesain, Cysteine Protease of <i>Trypanosoma brucei rhodesiense</i>

<b>Background/Objectives:</b> Rhodesain is a cysteine protease crucial for the life cycle of <i>Trypanosoma brucei rhodesiense</i>, a parasite that causes the lethal form of human African trypanosomiasis. For these reasons, rhodesain is considered an important target for the...

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Bibliographic Details
Main Authors: Carla Di Chio, Josè Starvaggi, Santo Previti, Fabiola De Luca, Benito Natale, Sandro Cosconati, Tanja Schirmeister, Maria Zappalà, Roberta Ettari
Format: Article
Language:English
Published: MDPI AG 2025-06-01
Series:Pharmaceuticals
Subjects:
rhodesain
drug combination
nitrile peptides
curcumin
synergistic effect
Online Access:https://www.mdpi.com/1424-8247/18/6/847
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