Functionality and translation fidelity characterization of mRNA vaccines using platform based mass spectrometry detection

Functionality and translation fidelity characterization of mRNA vaccines using platform based mass spectrometry detection

Abstract The success of mRNA-based therapeutics and vaccines is attributed to their rapid development, adaptability, and scalable production. Modified ribonucleotides like N1-methylpseudouridine enhance stability and reduce immunogenicity but were recently found to induce cellular immunity to off-ta...

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Bibliographic Details
Main Authors: Alyssa Q. Stiving, Benjamin W. Roose, Christopher Tubbs, Mark Haverick, Ashley Gruber, Richard R. Rustandi, Jesse Kuiper, Matthew Schombs, Hillary Schuessler, Xuanwen Li
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:npj Vaccines
Online Access:https://doi.org/10.1038/s41541-025-01082-4
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