Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome
Background. Accumulation of extracellular water (ECW) is a major clinical manifestation of nephrotic syndrome (NS) in children. Bioimpedance spectroscopy (BIS) is a simple, noninvasive technique that reflects body water volumes. BIS can further measure cell membrane capacitance (CM), which may be al...
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2019-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2019/4274856 |
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| author | Steven Brantlov Lars Jødal René Frydensbjerg Andersen Aksel Lange Søren Rittig Leigh C. Ward |
| author_facet | Steven Brantlov Lars Jødal René Frydensbjerg Andersen Aksel Lange Søren Rittig Leigh C. Ward |
| author_sort | Steven Brantlov |
| collection | DOAJ |
| description | Background. Accumulation of extracellular water (ECW) is a major clinical manifestation of nephrotic syndrome (NS) in children. Bioimpedance spectroscopy (BIS) is a simple, noninvasive technique that reflects body water volumes. BIS can further measure cell membrane capacitance (CM), which may be altered in NS. The aims of the study were to explore how BIS measurements could reflect disease status in NS, while avoiding prediction equations which are often only validated in adult populations. Methods. The study involved 8 children (2-10 years) with active NS (ANS group), 5 of which were also studied at NS remission (NSR group), as well as 38 healthy children of similar age (HC group). BIS measurements determined resistances RINF, RE, and RI (reflecting total body water, extracellular water, and intracellular water) and CM. Also resistance indices based on height (H) were considered, RI = H2/R. Results. It was found that RE and RINF were significantly lower in the ANS group than in both NSR and HC groups (p < 0.001). Corresponding resistance indices were significantly higher in the ANS group than in the NSR (p < 0.01) and the HC (p < 0.05) groups, in accordance with elevated water volumes in NS patients. Indices of intracellular water were not significantly different between groups. CM was significantly lower in the ANS group than in NSR and HC groups (p < 0.05). Conclusion. BIS could distinguish children with active NS from well-treated and healthy children. Studies with more children are warranted. |
| format | Article |
| id | doaj-art-764d66a53804450a9c4a2571cfd70f63 |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-764d66a53804450a9c4a2571cfd70f632025-02-03T06:01:10ZengWileyThe Scientific World Journal2356-61401537-744X2019-01-01201910.1155/2019/42748564274856Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic SyndromeSteven Brantlov0Lars Jødal1René Frydensbjerg Andersen2Aksel Lange3Søren Rittig4Leigh C. Ward5Department of Procurement & Clinical Engineering, Aarhus University Hospital, DenmarkDepartment of Nuclear Medicine, Aalborg University Hospital, DenmarkDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, DenmarkDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, DenmarkDepartment of Paediatrics and Adolescent Medicine, Aarhus University Hospital, DenmarkSchool of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, AustraliaBackground. Accumulation of extracellular water (ECW) is a major clinical manifestation of nephrotic syndrome (NS) in children. Bioimpedance spectroscopy (BIS) is a simple, noninvasive technique that reflects body water volumes. BIS can further measure cell membrane capacitance (CM), which may be altered in NS. The aims of the study were to explore how BIS measurements could reflect disease status in NS, while avoiding prediction equations which are often only validated in adult populations. Methods. The study involved 8 children (2-10 years) with active NS (ANS group), 5 of which were also studied at NS remission (NSR group), as well as 38 healthy children of similar age (HC group). BIS measurements determined resistances RINF, RE, and RI (reflecting total body water, extracellular water, and intracellular water) and CM. Also resistance indices based on height (H) were considered, RI = H2/R. Results. It was found that RE and RINF were significantly lower in the ANS group than in both NSR and HC groups (p < 0.001). Corresponding resistance indices were significantly higher in the ANS group than in the NSR (p < 0.01) and the HC (p < 0.05) groups, in accordance with elevated water volumes in NS patients. Indices of intracellular water were not significantly different between groups. CM was significantly lower in the ANS group than in NSR and HC groups (p < 0.05). Conclusion. BIS could distinguish children with active NS from well-treated and healthy children. Studies with more children are warranted.http://dx.doi.org/10.1155/2019/4274856 |
| spellingShingle | Steven Brantlov Lars Jødal René Frydensbjerg Andersen Aksel Lange Søren Rittig Leigh C. Ward Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome The Scientific World Journal |
| title | Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome |
| title_full | Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome |
| title_fullStr | Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome |
| title_full_unstemmed | Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome |
| title_short | Bioimpedance Resistance Indices and Cell Membrane Capacitance Used to Assess Disease Status and Cell Membrane Integrity in Children with Nephrotic Syndrome |
| title_sort | bioimpedance resistance indices and cell membrane capacitance used to assess disease status and cell membrane integrity in children with nephrotic syndrome |
| url | http://dx.doi.org/10.1155/2019/4274856 |
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