Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia

Limiting serine availability during tumor progression promotes muscle wasting in cancer cachexia

Abstract Cancer cachexia is a multifactorial syndrome characterized by a progressive loss of body weight occurring in about 80% of cancer patients, frequently representing the leading cause of death. Dietary intervention is emerging as a promising therapeutic strategy to counteract cancer-induced wa...

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Main Authors: Erica Pranzini, Livio Muccillo, Ilaria Nesi, Alice Santi, Caterina Mancini, Giulia Lori, Massimo Genovese, Tiziano Lottini, Giuseppina Comito, Anna Caselli, Annarosa Arcangeli, Lina Sabatino, Vittorio Colantuoni, Maria Letizia Taddei, Paolo Cirri, Paolo Paoli
Format: Article
Language:English
Published: Nature Publishing Group 2024-12-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02271-1
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https://doi.org/10.1038/s41420-024-02271-1

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