Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1

Combined dendritic cell and anti-TIGIT immunotherapy potentiates adaptive NK cells against HIV-1

Abstract Natural Killer (NK) cells are promising candidates for targeting persistently infected CD4 + T cells in people with HIV-1 (PWH). However, chronicity of HIV-1 infection impairs NK cell functionality, requiring additional strategies to potentiate their cytotoxic activity. This study demonstra...

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Main Authors: Ildefonso Sánchez-Cerrillo, María Agudo-Lera, Olga Popova, Ilya Tsukalov, Marta Calvet-Mirabent, Ignacio de los Santos, Lucio García-Fraile, Patricia Fuentes, Cristina Delgado-Arévalo, Juan Alcain, Nerea Sánchez-Gaona, Judith Grau-Expósito, María Lázaro-Díez, Cecilia Muñoz-Calleja, Arantzazu Alfranca, Meritxell Genescà, Julia G Prado, Vladimir Vrbanac, Alejandro Balazs, María José Buzón, María L Toribio, María A Muñoz-Fernández, Francisco Sánchez-Madrid, Enrique Martín-Gayo
Format: Article
Language:English
Published: Springer Nature 2025-06-01
Series:EMBO Molecular Medicine
Subjects:
Dendritic Cell
HIV
Natural Killer
TIGIT
TRAIL
Online Access:https://doi.org/10.1038/s44321-025-00255-x
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https://doi.org/10.1038/s44321-025-00255-x

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