Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine
Abstract Compounds that can induce oxidative stress in cancer cells while remaining nontoxic to healthy cells are extremely promising for potential anticancer drugs. 2,2′:6′,2′′-terpyridine-metal complexes possess these properties. The high level of activity (IC50 = 0.605 µM) of 2,2′:6′,2′′-terpyrid...
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Nature Portfolio
2024-11-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-024-77575-4 |
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| author | Katarzyna Malarz Patryk Ziola Dawid Zych Patryk Rurka Anna Mrozek-Wilczkiewicz |
| author_facet | Katarzyna Malarz Patryk Ziola Dawid Zych Patryk Rurka Anna Mrozek-Wilczkiewicz |
| author_sort | Katarzyna Malarz |
| collection | DOAJ |
| description | Abstract Compounds that can induce oxidative stress in cancer cells while remaining nontoxic to healthy cells are extremely promising for potential anticancer drugs. 2,2′:6′,2′′-terpyridine-metal complexes possess these properties. The high level of activity (IC50 = 0.605 µM) of 2,2′:6′,2′′-terpyridine-metal complexes on lung, breast, pancreatic, and glioblastoma multiforme cancer lines and their selectivity (SI > 41.32) on human normal fibroblasts were confirmed and presented in this paper. The mechanism of action of these compounds is associated with the generation of reactive oxygen species, which affects several cellular pathways and signals. The results demonstrate that 2,2′:6′,2′′-terpyridine-metal complexes affect cell cycle inhibition in the G0/G1 phase as well as the activation of apoptosis and autophagy cell death. These results were confirmed in several independent studies, including experiments measuring the fluorescence levels of reactive oxygen species, flow cytometry, and gene and protein analysis. |
| format | Article |
| id | doaj-art-7607070c75284fb7a89ff78c8fb8336d |
| institution | OA Journals |
| issn | 2045-2322 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-7607070c75284fb7a89ff78c8fb8336d2025-08-20T02:13:35ZengNature PortfolioScientific Reports2045-23222024-11-0114111510.1038/s41598-024-77575-4Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridineKatarzyna Malarz0Patryk Ziola1Dawid Zych2Patryk Rurka3Anna Mrozek-Wilczkiewicz4Department of Systems Biology and Engineering, Silesian University of TechnologyA. Chełkowski Institute of Physics, University of Silesia in KatowiceFaculty of Chemistry, University of OpoleA. Chełkowski Institute of Physics, University of Silesia in KatowiceDepartment of Systems Biology and Engineering, Silesian University of TechnologyAbstract Compounds that can induce oxidative stress in cancer cells while remaining nontoxic to healthy cells are extremely promising for potential anticancer drugs. 2,2′:6′,2′′-terpyridine-metal complexes possess these properties. The high level of activity (IC50 = 0.605 µM) of 2,2′:6′,2′′-terpyridine-metal complexes on lung, breast, pancreatic, and glioblastoma multiforme cancer lines and their selectivity (SI > 41.32) on human normal fibroblasts were confirmed and presented in this paper. The mechanism of action of these compounds is associated with the generation of reactive oxygen species, which affects several cellular pathways and signals. The results demonstrate that 2,2′:6′,2′′-terpyridine-metal complexes affect cell cycle inhibition in the G0/G1 phase as well as the activation of apoptosis and autophagy cell death. These results were confirmed in several independent studies, including experiments measuring the fluorescence levels of reactive oxygen species, flow cytometry, and gene and protein analysis.https://doi.org/10.1038/s41598-024-77575-42,2′:6′,2′′-terpyridineAnticancer activityReactive oxygen speciesOxidative stressApoptosisAutophagy |
| spellingShingle | Katarzyna Malarz Patryk Ziola Dawid Zych Patryk Rurka Anna Mrozek-Wilczkiewicz Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine Scientific Reports 2,2′:6′,2′′-terpyridine Anticancer activity Reactive oxygen species Oxidative stress Apoptosis Autophagy |
| title | Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| title_full | Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| title_fullStr | Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| title_full_unstemmed | Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| title_short | Imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| title_sort | imbalance of redox homeostasis and altered cellular signaling induced by the metal complexes of terpyridine |
| topic | 2,2′:6′,2′′-terpyridine Anticancer activity Reactive oxygen species Oxidative stress Apoptosis Autophagy |
| url | https://doi.org/10.1038/s41598-024-77575-4 |
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