Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery
The use of hydrogel-based niches for therapy delivery enables the concentration of active components and cells in a targeted area. This approach enhances efficacy while minimizing systemic side effects by spatially controlling the release of the therapy. Precise tuning of the matrix's chemical...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-04-01
|
| Series: | Materials Today Bio |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000687 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832583095573807104 |
|---|---|
| author | Veronica Torresan Alessandro Gandin Paolo Contessotto Francesca Zanconato Giovanna Brusatin |
| author_facet | Veronica Torresan Alessandro Gandin Paolo Contessotto Francesca Zanconato Giovanna Brusatin |
| author_sort | Veronica Torresan |
| collection | DOAJ |
| description | The use of hydrogel-based niches for therapy delivery enables the concentration of active components and cells in a targeted area. This approach enhances efficacy while minimizing systemic side effects by spatially controlling the release of the therapy. Precise tuning of the matrix's chemical properties and control of both material degradation and release profile of biologically active components are required to reduce the optimal dose and extend its therapeutic effect. Here we aimed to develop an injectable hydrogel that can fulfill all these requirements. We designed a system based on hyaluronic acid, crosslinked via click-reaction with multi-arm polyethyleneglycol and functionalized with RGD peptides. Additionally, we incorporated thiol-modified heparin into the formulation, which provides specific binding sites for cytokines. Our results indicate that heparin incorporation can delay cytokine release, while the release of nanocarriers can be regulated by adjusting the crosslinking degree. This design modulates pore size and degradation time, while preserving the injectability of the niche. In conclusion, this system offers a versatile and efficient delivery platform suitable for therapeutic applications in a wide range of diseases. |
| format | Article |
| id | doaj-art-75e66446fbe24cd49c9f2512b908819b |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-75e66446fbe24cd49c9f2512b908819b2025-01-29T05:01:39ZengElsevierMaterials Today Bio2590-00642025-04-0131101510Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy deliveryVeronica Torresan0Alessandro Gandin1Paolo Contessotto2Francesca Zanconato3Giovanna Brusatin4Department of Industrial Engineering, University of Padova and INSTM, Via Marzolo 9, Padova, 35131, ItalyDepartment of Industrial Engineering, University of Padova and INSTM, Via Marzolo 9, Padova, 35131, ItalyDepartment of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, Padova, 35131, ItalyDepartment of Molecular Medicine, University of Padova, Via Ugo Bassi 58/B, Padova, 35131, ItalyDepartment of Industrial Engineering, University of Padova and INSTM, Via Marzolo 9, Padova, 35131, Italy; Corresponding author.The use of hydrogel-based niches for therapy delivery enables the concentration of active components and cells in a targeted area. This approach enhances efficacy while minimizing systemic side effects by spatially controlling the release of the therapy. Precise tuning of the matrix's chemical properties and control of both material degradation and release profile of biologically active components are required to reduce the optimal dose and extend its therapeutic effect. Here we aimed to develop an injectable hydrogel that can fulfill all these requirements. We designed a system based on hyaluronic acid, crosslinked via click-reaction with multi-arm polyethyleneglycol and functionalized with RGD peptides. Additionally, we incorporated thiol-modified heparin into the formulation, which provides specific binding sites for cytokines. Our results indicate that heparin incorporation can delay cytokine release, while the release of nanocarriers can be regulated by adjusting the crosslinking degree. This design modulates pore size and degradation time, while preserving the injectability of the niche. In conclusion, this system offers a versatile and efficient delivery platform suitable for therapeutic applications in a wide range of diseases.http://www.sciencedirect.com/science/article/pii/S2590006425000687Injectable hydrogelsHydrogel nichesTherapies delivery |
| spellingShingle | Veronica Torresan Alessandro Gandin Paolo Contessotto Francesca Zanconato Giovanna Brusatin Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery Materials Today Bio Injectable hydrogels Hydrogel niches Therapies delivery |
| title | Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery |
| title_full | Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery |
| title_fullStr | Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery |
| title_full_unstemmed | Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery |
| title_short | Injectable hyaluronic acid-based hydrogel niches to create localized and time-controlled therapy delivery |
| title_sort | injectable hyaluronic acid based hydrogel niches to create localized and time controlled therapy delivery |
| topic | Injectable hydrogels Hydrogel niches Therapies delivery |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000687 |
| work_keys_str_mv | AT veronicatorresan injectablehyaluronicacidbasedhydrogelnichestocreatelocalizedandtimecontrolledtherapydelivery AT alessandrogandin injectablehyaluronicacidbasedhydrogelnichestocreatelocalizedandtimecontrolledtherapydelivery AT paolocontessotto injectablehyaluronicacidbasedhydrogelnichestocreatelocalizedandtimecontrolledtherapydelivery AT francescazanconato injectablehyaluronicacidbasedhydrogelnichestocreatelocalizedandtimecontrolledtherapydelivery AT giovannabrusatin injectablehyaluronicacidbasedhydrogelnichestocreatelocalizedandtimecontrolledtherapydelivery |