Rapid cleavage of 6-[18F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules

Rapid cleavage of 6-[18F]fluoronicotinic acid prosthetic group governs BT12 glioblastoma xenograft uptake: implications for radiolabeling design of biomolecules

Abstract Background Peptides radiolabeled with fluorine-18 are frequently synthesized using prosthetic groups. Among them, activated esters of 6-[18F]fluoronicotinic acid ([18F]FNA) have been prepared and successfully employed for 18F-labeling of diverse biomolecules, including peptides. The utility...

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Main Authors: Pyry Dillemuth, Abiodun Ayo, Xiaoqing Zhuang, Petter Lövdahl, Heidi Liljenbäck, Salli Kärnä, Tatsiana Auchynnikava, Jonne Kunnas, Jesse Ponkamo, Maxwell W. G. Miner, Johan Rajander, Jessica M. Rosenholm, Anne Roivainen, Anu J. Airaksinen, Pirjo Laakkonen, Xiang-Guo Li
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:EJNMMI Radiopharmacy and Chemistry
Subjects:
Fluorine-18
6-[18F]fluoronicotinic acid
Peptide radiolabeling
PET
Prosthetic group
Online Access:https://doi.org/10.1186/s41181-025-00368-1
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https://doi.org/10.1186/s41181-025-00368-1

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