The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption

The role of TRPV4 in acute sleep deprivation-induced memory impairment: Mechanisms of calcium dysregulation and synaptic plasticity disruption

Acute sleep deprivation (ASD) impairs memory formation, but the underlying mechanisms remain unclear. In this study, we employed an ASD model combined with fear conditioning to investigate these mechanisms. mRNA sequencing revealed upregulated expression of Transient Receptor Potential Vanilloid 4 (...

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Bibliographic Details
Main Authors: Meimei Guo, Feiyang Zhang, Sha Liu, Yi Zhang, Lesheng Wang, Jian Song, Wei Wei, Xiang Li
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Cell Insight
Subjects:
Learning and memory
Sleep deprivation (SD)
Transient receptor potential vanilloid 4 (TRPV4)
Postsynaptic density protein 95 (PSD95)
Synaptic plasticity
Online Access:http://www.sciencedirect.com/science/article/pii/S2772892725000148
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http://www.sciencedirect.com/science/article/pii/S2772892725000148

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